Guo-Chun Zhou Selected Research

andrographolide

1/2022	Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71.
1/2022	The new andrographolide derivative AGS-30 induces apoptosis in human colon cancer cells by activating a ROS-dependent JNK signalling pathway.
12/2021	Synthesis and Characterization of Andrographolide Derivatives as Regulators of βAPP Processing in Human Cells.
12/2021	Discovery of 14S-(2'-chloro-4'-nitrophenoxy)-8R/S,17-epoxy andrographolide as EV-A71 infection inhibitor.
10/2020	Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection.
2/2020	Design, synthesis and discovery of andrographolide derivatives against Zika virus infection.
1/2020	AGS-30, an andrographolide derivative, suppresses tumor angiogenesis and growth in vitro and in vivo.
1/2019	Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice.
2/2018	Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity.
10/2016	Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs.

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Guo-Chun Zhou Research Topics

Disease

8	Infections 01/2022 - 05/2004
8	Neoplasms (Cancer) 01/2022 - 06/2010
2	Colonic Neoplasms (Colon Cancer) 01/2022 - 01/2020
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 12/2021
2	Zika Virus Infection 11/2020 - 02/2020
2	Inflammation (Inflammations) 01/2019 - 02/2018
1	Alzheimer Disease (Alzheimer's Disease) 12/2021
1	Neuroblastoma 12/2021
1	Foot and Mouth Disease Hand (Hand, Foot, Mouth Disease) 12/2021
1	Communicable Diseases (Infectious Diseases) 02/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Colitis 01/2019
1	Liver Diseases (Liver Disease) 10/2018
1	Body Weight (Weight, Body) 10/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2018
1	Dengue (Dengue Fever) 01/2017
1	Pneumonia (Pneumonitis) 01/2017

Drug/Important Bio-Agent (IBA)

10	andrographolideIBA 01/2022 - 10/2016
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2004
3	Antiviral Agents (Antivirals)IBA 01/2022 - 11/2020
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2020
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2019 - 02/2018
1	andrographolide sulfonateIBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Caspase 9IBA 01/2022
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2022
1	indolineIBA 01/2022
1	Caspase 3 (Caspase-3)IBA 01/2022
1	DiterpenesIBA 12/2021
1	Amyloid (Amyloid Fibrils)IBA 12/2021
1	Peptides (Polypeptides)IBA 12/2021
1	Epoxy Compounds (Epoxides)IBA 12/2021
1	imidazoloneIBA 11/2020
1	1,2,3,4-tetrahydroquinolineIBA 11/2020
1	quinolineIBA 02/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020
1	VaccinesIBA 01/2020
1	Dextran SulfateIBA 01/2019
1	CateninsIBA 01/2019
1	Janus KinasesIBA 10/2018
1	Carbon Tetrachloride (Tetrachloromethane)IBA 10/2018
1	N-dodecyl-L-lysine amideIBA 10/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2018
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2017
1	pyrrolidineIBA 01/2017
1	ChemokinesIBA 01/2017
1	CytokinesIBA 01/2017
1	fumagillinIBA 01/2013
1	miltipoloneIBA 04/2011
1	Chelating AgentsIBA 04/2011
1	Antineoplastic Agents (Antineoplastics)IBA 12/2010
1	Growth InhibitorsIBA 12/2010
1	QuinonesIBA 06/2010
1	PhenolsIBA 06/2010
1	1,3-cyclohexadieneIBA 06/2010
1	Cholera ToxinIBA 05/2004
1	ExotoxinsIBA 05/2004
1	Pertussis ToxinIBA 05/2004
1	Diphtheria ToxinIBA 05/2004